Posts for tag: hepatitis c
Hepatitis C is an infectious disease that causes liver inflammation, sometimes leading to serious liver damage. Most people have no symptoms right after they have been infected, and since any symptoms are likely to go away in a few weeks, you may not know you have Hepatitis C for a long time. Here are the most common signs of Hepatitis C.
Jaundice is a yellowish appearance of the whites of the eyes due to high bilirubin levels. Normally bilirubin gets broken down in the liver and released from the body in the stool. But if the liver is damaged, it cannot properly process bilirubin.
2. Dark Urine
Urine naturally has some yellow pigments called urobilin or urochrome. The color of the urine can vary when certain medications are taken and when foods of certain types are consumed. Chronic dark-colored urine can be related to serious liver conditions, including Hepatitis C and cirrhosis.
3. Chronic Fatigue
The severity of this fatigue differs from person to person. Some individuals are able to work, but then feel burned out in the evening. Some people spend a large amount of time sleeping. However, someone people feel very tired after a good night's sleep. The fatigue associated with Hepatitis C often improves with treatment.
4. Aches and Pains
Some people with Hepatitis C experience abdominal pain. Many suffer from aches and pains in their joints. A variety of different joints can be involved but the most common are in the wrists and hands. The pains can range from mild to severe. In such cases, medications can be used to ease the pain.
5. Poor Appetite
Loss of appetite implies that hunger is absent. Your appetite may worsen if you have cirrhosis or liver failure. Loss of appetite can also be caused by other diseases and conditions. Some of the conditions can be temporary, such as appetite loss from the effects of medication.
6. Low-grade Fever
Everyone gets a fever from time to time. Most usually don't indicate anything serious. However, some people with Hepatitis C experience a low-grade fever (fever up to 102°F). You should book an appointment with a doctor if you've had a fever for more than three days.
7. Cognitive Changes
Some people with Hepatitis C experience problems with concentration, short-term memory, and completing complex mental tasks such as mental arithmetic. Studies have shown that about half of those with Hepatitis C experience cognitive disturbances.
Many people are surprised to learn that they have been infected with Hepatitis C. Some people feel overwhelmed by the changes they need to make in their lives. At a time when life feels out of control, remember that you can take an active role in your health- and your life.
Hepatitis C Facts
- ~3.5 million Americans live with HCV infection.
- >15,000 Americans will become infected with HCV every year.
- >15,000 Americans will die every year from complications of HCV.
- 80% of people who get exposed to HCV will develop a chronic infection.
- HCV is acquired through direct exposure to blood of someone who is infected.
- 15-30% of people with chronic HCV will develop cirrhosis or other complications, most after more than 20 years.
- HCV with heavy alcohol use increases the risk of cirrhosis 100-fold
- Currently, no vaccine is available.
A renaissance in the treatment of Hepatitis C Virus (HCV)
Twenty-five years of HCV’s dark ages are over. Plagued by poor understanding of HCV, primitive and barbaric treatments (specifically interferon) with significant toxicity and limited success were all we had to offer—until now. In 2009, scientists discovered how to replicate HCV in mice, opening the doors to a renaissance in HCV drug development.
The new age Hepatitis C treatment
Within the past year, interferon-free drug regimens for every genotype (sub-type of HCV) have come to market. While we are still gaining important experience with these drugs, a few things are clear: The new HCV drugs are very effective with greater than 90% cure, even in those with cirrhosis, and are easy to take with minimal side effects. Better yet, several additional drugs are currently under study with very promising results; the near future will offer even more effective, shorter, easier, and less costly treatment regimens.
Hepatitis C genotype 1 (and 4)
Type 1 HCV accounts for more than 70% of infections in the United States and traditionally was very resistant to treatment. Harvoni© became available October 10th, 2014 representing the first interferon-free regimen consisting of one pill (containing ledipasvir and sofosbuvir) taken once a day for 12-weeks with >94% clearance. Side effects include headaches and fatigue, but not a single study participant stopped the drugs due to side effects—a gigantic leap forward compared to interferon-based treatments. More recently, Viekira© and Olysio-Sovaldi© treatment regimens were approved, with the promise of several more to come in 2015.
Hepatitis C genotype 2 and 3
Approval of Sovaldi© in combination with Ribavirin© has improved cure rates for HCV genotypes 2 and 3 from 70% to greater than 90%. However, this combination eliminates the need for interferon, but still relies on ribavirin—a drug with the potentially serious side effect of anemia (low red blood cell counts.) Better regimens, which avoid both interferon and ribavirin, are just around the corner.
Who should get treated for hepatitis C in this new era?
With such great new medications, it would seem that everyone should get treated, except for one serious problem: cost. The new drug regimens cost in excess of $80,000; it would cost 280 billion dollars (for the drugs alone) to treat every American with Hepatitis C. Obviously, insurance companies have balked at the thought of an $80,000 drug, and perhaps rightfully so. Less than a third of all persons infected with HCV will ever develop cirrhosis or complications—treatments should be offered to patients who are at a high risk of developing cirrhosis. Fortunately, for most it takes 30 years or more to develop cirrhosis. See a Gastroenterologist to determine if, and when, treatment might be needed.